SERPINF2 and SERPINB12

Data Source:
HPRD (in vitro)

		SERPINF2	SERPINB12
Description		serpin family F member 2	serpin family B member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Cell Surface Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Space Cytoplasm Plasma Membrane Collagen-containing Extracellular Matrix Ficolin-1-rich Granule Membrane
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity	Serine-type Endopeptidase Inhibitor Activity Enzyme Binding
	Biological Process	Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Platelet Degranulation Acute-phase Response Response To Organic Substance Negative Regulation Of Plasminogen Activation Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Positive Regulation Of Collagen Biosynthetic Process Fibrinolysis Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Fibrinolysis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Catabolic Process Neutrophil Degranulation
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Neutrophil degranulation
Drugs		Ocriplasmin Copper
Diseases		Alpha-2-plasmin inhibitor (a2-PI) deficiency
GWAS		Blood protein levels ( 29875488) Calcium levels ( 24068962 20705733) Serum albumin level ( 23022100 29403010) Urate levels ( 31578528)
Interacting Genes		17 interacting genes: BCAP31 CFD CTRB1 DEFA1 ELANE F11 F13A1 FGA KLK13 KLK2 KLK6 PLAU PLG PRSS1 SERPINB12 SSR1 TGM2	2 interacting genes: SERPINF2 UCHL5
Entrez ID		5345	89777
HPRD ID		02029	11548
Ensembl ID		ENSG00000167711	ENSG00000166634
Uniprot IDs		P08697	Q96P63
PDB IDs
Enriched GO Terms of Interacting Partners?
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