SYNE4 and CD47

Data Source:
BioGRID (two hybrid)

		SYNE4	CD47
Description		spectrin repeat containing nuclear envelope family member 4	CD47 molecule
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GO Annotations	Cellular Component	Integral Component Of Nuclear Outer Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Establishment Of Epithelial Cell Apical/basal Polarity	Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 ATP Export Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways			Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		56 interacting genes: ABT1 ADIPOQ BRICD5 C3orf52 CD47 CEP19 CLDN19 CLDN7 CLDN8 CLEC7A CMTM5 CSGALNACT2 CSNK2B CXCL9 DEFB121 ECE2 EDDM3B EMP1 ENTPD3 FAM241B FATE1 GADD45A GSK3B IGFBP5 ITM2B KLHL12 KLRG1 KTN1 MALL MARCHF2 NAGK OCLN OLFM4 OSTCP1 PAQR5 PLPP6 RIPPLY2 RPS6KA6 SEC22A SEC23B SENP2 SFTPC SLN SMCO4 TCEA2 TMEM115 TMEM140 TMEM147 TMEM182 TMEM248 TMPRSS4 TRIM69 TSPAN15 VTI1B ZNF250 ZNF648	16 interacting genes: BNIP3 EPB42 FAS GNAI1 ITGAV MTIF3 MUC1 P2RY2 PTK2 PVR RHAG SIRPA SYNE4 THBS1 TMEM167B UBQLN1
Entrez ID		163183	961
HPRD ID		08776	03017
Ensembl ID		ENSG00000181392	ENSG00000196776
Uniprot IDs		Q8N205	A0A0A1TSG4 Q08722
PDB IDs		6R16	2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU
Enriched GO Terms of Interacting Partners?
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