CD47 and P2RY2

Data Source:
HPRD (in vivo)

		CD47	P2RY2
Description		CD47 molecule	purinergic receptor P2Y2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity	Protein Binding Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Interferon-gamma Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Neutrophil Degranulation Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 ATP Export Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Cellular Ion Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Blood Vessel Diameter Maintenance
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation	G alpha (q) signalling events P2Y receptors Surfactant metabolism
Drugs			Promethazine Suramin Denufosol INS 316
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)	Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Monocyte percentage of white cells ( 32888494) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)
Interacting Genes		16 interacting genes: BNIP3 EPB42 FAS GNAI1 ITGAV MTIF3 MUC1 P2RY2 PTK2 PVR RHAG SIRPA SYNE4 THBS1 TMEM167B UBQLN1	7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC
Entrez ID		961	5029
HPRD ID		03017	02499
Ensembl ID		ENSG00000196776	ENSG00000175591
Uniprot IDs		A0A0A1TSG4 Q08722	P41231
PDB IDs		2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU	1Z8E
Enriched GO Terms of Interacting Partners?
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