USP54 and HNF1B

Data Source:
BioGRID (two hybrid)

		USP54	HNF1B
Description		ubiquitin specific peptidase 54	HNF1 homeobox B
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation	Kidney Development Regulation Of Transcription By RNA Polymerase II Response To Carbohydrate Response To Organic Cyclic Compound Insulin Secretion Pancreas Development Circadian Regulation Of Gene Expression Regulation Of Pronephros Size Pronephric Nephron Tubule Development Response To Drug Positive Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Pronephros Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Protein-DNA Complex Assembly Hepatocyte Differentiation
Pathways			Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Regulation of gene expression in early pancreatic precursor cells
Drugs
Diseases			Maturity onset diabetes of the young (MODY) Type II diabetes mellitus Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS		Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 28892062) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Endometrial cancer ( 30093612 27008869 21499250 27135401) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Epithelial ovarian cancer ( 25581431) Frontotemporal dementia ( 26154020) Gallstone disease ( 30504769) Medication use (drugs used in diabetes) ( 31015401) Neuritic plaque ( 25188341) Ovarian cancer ( 23535730) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Prostate cancer ( 20676098 18264096 18264097 30410027 31562322 25939597 26443449 27262462) Prostate-specific antigen levels ( 30410027 28139693) Serum prostate-specific antigen levels ( 21160077) Testicular germ cell tumor ( 25877299 28604728 28604732) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 22961080 32499647 20581827 30718926 28869590)
Interacting Genes		88 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76	17 interacting genes: ATF1 BPIFA1 C10orf55 CREB1 CREBBP CRX H3C1 HNF1A KRTAP26-1 MLLT10 OTX2 OXER1 PCBD1 POU6F2 UFSP1 USP54 VAC14
Entrez ID		159195	6928
HPRD ID		15641	08926
Ensembl ID		ENSG00000166348	ENSG00000275410
Uniprot IDs		B7Z7X1 Q70EL1	A0A087WZC2 A0A0C4DGS8 E0YMJ6 P35680 Q6FHW6
PDB IDs			2DA6 2H8R 5K9S
Enriched GO Terms of Interacting Partners?
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