GRK3 and BDKRB2

Data Source:
HPRD (in vivo, in vitro)

		GRK3	BDKRB2
Description		G protein-coupled receptor kinase 3	bradykinin receptor B2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Receptor Internalization	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		ATP	Anatibant Icatibant Labradimil
Diseases
GWAS			Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		10 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 HSPB1 OPRM1 SMURF1	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		157	624
HPRD ID		00183	00213
Ensembl ID		ENSG00000100077	ENSG00000168398
Uniprot IDs		A0A024R1D8 P35626 Q8N433	P30411
PDB IDs
Enriched GO Terms of Interacting Partners?
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