Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
DTX3L and UBE2K
Data Source:
BioGRID
(two hybrid)
DTX3L
UBE2K
Description
deltex E3 ubiquitin ligase 3L
ubiquitin conjugating enzyme E2 K
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Early Endosome
Cytosol
Early Endosome Membrane
Protein-containing Complex
Nucleus
Cytosol
Filopodium Tip
Molecular Function
Ubiquitin-protein Transferase Activity
Enzyme Inhibitor Activity
Protein Binding
Enzyme Activator Activity
Enzyme Binding
Histone Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
STAT Family Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
Positive Regulation Of Defense Response To Virus By Host
Double-strand Break Repair
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Notch Signaling Pathway
Endosome To Lysosome Transport
Histone Monoubiquitination
Protein Transport
Viral Process
Protein Ubiquitination
Positive Regulation Of Protein Binding
Histone H2A Ubiquitination
Histone H2B Ubiquitination
Positive Regulation Of Chromatin Binding
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Ubiquitin-protein Transferase Activity
Defense Response To Virus
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of NAD+ ADP-ribosyltransferase Activity
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Receptor Catabolic Process
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-threonine Phosphorylation
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K48-linked Ubiquitination
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Low density lipoprotein cholesterol levels (
32154731
)
Major depressive disorder (
22472876
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Plasma amyloid beta peptide concentrations (ABx-40) (
24535457
)
Platelet count (
32888494
)
Interacting Genes
20 interacting genes:
DTX1
H2AZ2
ITCH
PARP9
PHF7
RNF111
SPG21
TRIM9
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2R2
UBE2W
95 interacting genes:
AMFR
ANAPC11
BARD1
BFAR
BIRC7
BIRC8
BRCA1
CASP12
CBLC
CCNC
CDC6
DDI1
DDX58
DIABLO
DTX3
DTX3L
DZIP3
EXOSC7
FZR1
HTT
ITCH
ITSN1
KRIT1
LRSAM1
MAP3K1
MARCHF3
MARCHF7
MDM2
MEOX2
MID1
MID2
MIPOL1
MKRN2
MKRN3
NEDD4L
NEDD8
NFKB1
NUB1
PAX6
PIAS4
PICK1
PJA1
PRKN
PRPF40A
PRRG4
RBCK1
RC3H2
REL
RING1
RLIM
RNF111
RNF114
RNF125
RNF138
RNF144A
RNF166
RNF167
RNF182
RNF183
RNF185
RNF2
RNF31
RNF32
RNF4
RNF41
RNF5
SDCBP
SENP1
SH3RF1
SIAH1
SMURF1
TP53
TRAF7
TRAIP
TRIM2
TRIM27
TRIM3
TRIM31
TRIM34
TRIM35
TRIM39
TRIM43
TRIM5
TRIM50
TRIM63
TSN
UBA1
UBB
UBE2I
UBOX5
UHRF2
USP1
WWP2
ZDHHC17
ZNF384
Entrez ID
151636
3093
HPRD ID
16843
04165
Ensembl ID
ENSG00000163840
ENSG00000078140
Uniprot IDs
Q8TDB6
B3KSH4
B4DIZ2
P61086
PDB IDs
3PG6
1YLA
2O25
3E46
3F92
3K9O
3K9P
5DFL
6IF1
6JB6
6JB7
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?