CTSV and PDGFRL

Data Source:
BioGRID (two hybrid)

		CTSV	PDGFRL
Description		cathepsin V	platelet derived growth factor receptor like
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Lumen	Cellular_component Extracellular Region
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity
	Biological Process	Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Regulation Of Keratinocyte Differentiation Proteolysis Involved In Cellular Protein Catabolic Process	G Protein-coupled Receptor Signaling Pathway Biological_process Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Endosomal/Vacuolar pathway Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs		3-amino-5-phenylpentane 4-Methylpiperazin-1-Yl Carbonyl Group
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hippocampal volume in normal cognition ( 29274321) Placental abruption ( 29884306) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma parathyroid hormone levels ( 30134803) Spatial memory ( 31596458) Sphingomyelin 24:0 levels ( 31560688)
Interacting Genes		13 interacting genes: APC BMPR1A BRAF BUB1 CDKN2A CTNNA1 DCC DLC1 MLH1 MLH3 PDGFRL RB1 SRC	24 interacting genes: ASPH BAAT CCDC180 CTSV FANCC FBP2 HRAS MAP2K1 MAPK12 MAPK3 MBP NANS PFKM PPP2CB PPP3R2 RANGAP1 SFRP4 SMAD1 SPARCL1 TBC1D2 TGFB1 TMEM129 XPA ZNF510
Entrez ID		1515	5157
HPRD ID		04495	05206
Ensembl ID		ENSG00000136943	ENSG00000104213
Uniprot IDs		A0A024R141 B2R717 O60911	Q15198
PDB IDs		1FH0 3H6S 3KFQ
Enriched GO Terms of Interacting Partners?
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