CST3 and PDZD2

Data Source:
HPRD (in vitro)

		CST3	PDZD2
Description		cystatin C	PDZ domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding
	Biological Process	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization	Cell Adhesion
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Blood protein levels ( 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)	Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Chronic obstructive pulmonary disease ( 29394082) Corpus callosum central volume ( 31530798) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Myocardial infarction ( 26708285) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Renal cell carcinoma ( 23184150) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Reticulocyte fraction of red cells ( 32888494) Self-reported childhood asthma in adult smokers ( 30373671) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Working memory ( 31598132)
Interacting Genes		9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	5 interacting genes: ADGRB1 CST3 CTNND2 NRXN1 PKP4
Entrez ID		1471	23037
HPRD ID		05056	10142
Ensembl ID		ENSG00000101439	ENSG00000133401
Uniprot IDs		A0A0K0K1J1 P01034	A0A024RE15 O15018
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV
Enriched GO Terms of Interacting Partners?
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