CST3 and CTSL

Data Source:
HPRD (in vitro)

		CST3	CTSL
Description		cystatin C	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Apical Plasma Membrane Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling Supramolecular Fiber Organization	Toll-like Receptor Signaling Pathway Adaptive Immune Response Proteolysis Immune Response Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Keratinocyte Differentiation Viral Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Cellular Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Attachment and Entry
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Blood protein levels ( 28240269) Chronic kidney disease ( 20383146) Cystatin C ( 17903292) Glomerular filtration rate (cystatin C) ( 28452372) Plasma cystastin c levels in acute coronary syndrome ( 24952865)
Interacting Genes		9 interacting genes: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115	28 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		1471	1514
HPRD ID		05056	00293
Ensembl ID		ENSG00000101439	ENSG00000135047
Uniprot IDs		A0A0K0K1J1 P01034	A0A024R276 P07711 Q9HBQ7
PDB IDs		1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA 6ROA 6RPV	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8
Enriched GO Terms of Interacting Partners?
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