CSK and PTPN18

Data Source:
HPRD (two hybrid, in vitro)

		CSK	PTPN18
Description		C-terminal Src kinase	protein tyrosine phosphatase non-receptor type 18
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Raft Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Peptidyl-tyrosine Phosphorylation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Negative Regulation Of Bone Resorption Protein Autophosphorylation Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Blastocyst Formation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Cellular Response To Cytokine Stimulus Negative Regulation Of ERBB Signaling Pathway
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling PD-1 signaling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3	Downregulation of ERBB2 signaling Interleukin-37 signaling
Drugs		Dasatinib Staurosporine TG-100801 Fostamatinib
Diseases
GWAS		Blood pressure ( 21909110) Blood protein levels ( 30072576) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 26390057 19430479 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Serum albumin level ( 29403010) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
Interacting Genes		51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212	11 interacting genes: AATK ABL1 ARHGAP5 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC
Entrez ID		1445	26469
HPRD ID		00496	05961
Ensembl ID		ENSG00000103653	ENSG00000072135
Uniprot IDs		A8K3B6 B2R6Q4 P41240	Q99952
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	2OC3 4GFU 4GFV 4NND
Enriched GO Terms of Interacting Partners?
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