PTPN18 and PSTPIP1

Data Source:
HPRD (in vivo)

		PTPN18	PSTPIP1
Description		protein tyrosine phosphatase non-receptor type 18	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Uropod Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding	Protein Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Blastocyst Formation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Cellular Response To Cytokine Stimulus Negative Regulation Of ERBB Signaling Pathway	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Actin Filament Polymerization Innate Immune Response
Pathways		Downregulation of ERBB2 signaling Interleukin-37 signaling	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS			Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: AATK ABL1 ARHGAP5 CSK EGFR ERBB2 GAB1 PSTPIP1 PSTPIP2 SRC TEC	64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		26469	9051
HPRD ID		05961	05891
Ensembl ID		ENSG00000072135	ENSG00000140368
Uniprot IDs		Q99952	A0A0S2Z5P3 O43586
PDB IDs		2OC3 4GFU 4GFV 4NND	2DIL
Enriched GO Terms of Interacting Partners?
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