CSK and TLR3

Data Source:
HPRD (in vivo)

		CSK	TLR3
Description		C-terminal Src kinase	toll like receptor 3
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Raft Extracellular Exosome	Golgi Membrane Extracellular Space Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Extracellular Matrix Endolysosome Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding	Double-stranded RNA Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Peptidyl-tyrosine Phosphorylation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Negative Regulation Of Bone Resorption Protein Autophosphorylation Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus	Microglial Cell Activation Toll-like Receptor Signaling Pathway Regulation Of Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Hyperosmotic Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation Male Gonad Development Detection Of Virus Positive Regulation Of Gene Expression Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Drug Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To DsRNA Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Necroptotic Process Cellular Response To Mechanical Stimulus Cellular Response To Interferon-gamma Cellular Response To Exogenous DsRNA Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling PD-1 signaling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3	Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex
Drugs		Dasatinib Staurosporine TG-100801 Fostamatinib
Diseases
GWAS		Blood pressure ( 21909110) Blood protein levels ( 30072576) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 26390057 19430479 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Serum albumin level ( 29403010) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)	Autoimmune thyroid disease ( 32581359) Breast size ( 22747683) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212	10 interacting genes: CD14 CHEK2 CSK HLA-DRA MAP2K6 MYD88 RNF216 TICAM1 TICAM2 TRAF6
Entrez ID		1445	7098
HPRD ID		00496	04324
Ensembl ID		ENSG00000103653	ENSG00000164342
Uniprot IDs		A8K3B6 B2R6Q4 P41240	O15455
PDB IDs		1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ	1ZIW 2A0Z 2MK9 2MKA 3ULU 3ULV 5GS0
Enriched GO Terms of Interacting Partners?
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