MAPK14 and MAPK3

Data Source:
HPRD (in vitro, in vivo)

		MAPK14	MAPK3
Description		mitogen-activated protein kinase 14	mitogen-activated protein kinase 3
Image
GO Annotations	Cellular Component	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Speck Secretory Granule Lumen Glutamatergic Synapse Ficolin-1-rich Granule Lumen	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Pseudopodium Protein-containing Complex
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Mitogen-activated Protein Kinase P38 Binding NFAT Protein Binding	Phosphotyrosine Residue Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Phosphatase Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	DNA Damage Checkpoint Activation Of MAPK Activity Cell Morphogenesis Cartilage Condensation Angiogenesis Placenta Development Chondrocyte Differentiation Glucose Metabolic Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Chemotaxis Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ras Protein Signal Transduction Skeletal Muscle Tissue Development Positive Regulation Of Gene Expression Positive Regulation Of Myotube Differentiation Peptidyl-serine Phosphorylation Fatty Acid Oxidation Regulation Of Ossification Osteoclast Differentiation Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Response To Muramyl Dipeptide Positive Regulation Of Interleukin-12 Production Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch P38MAPK Cascade Positive Regulation Of Protein Import Into Nucleus Signal Transduction In Response To DNA Damage Neutrophil Degranulation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Brown Fat Cell Differentiation Stress-induced Premature Senescence Cellular Response To Virus Regulation Of Synaptic Membrane Adhesion Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myoblast Fusion Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Reactive Oxygen Species Metabolic Process	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Transcription Initiation From RNA Polymerase I Promoter Protein Phosphorylation Apoptotic Process DNA Damage Induced Protein Phosphorylation Cell Cycle Cell Surface Receptor Signaling Pathway Axon Guidance Aging Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Phosphorylation Peptidyl-serine Phosphorylation Sensory Perception Of Pain Arachidonic Acid Metabolic Process Platelet Activation Regulation Of Ossification BMP Signaling Pathway Regulation Of Cellular PH Thyroid Gland Development Positive Regulation Of Cyclase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Histone Phosphorylation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Positive Regulation Of Histone Acetylation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Outer Ear Morphogenesis Response To Exogenous DsRNA Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Decidualization Thymus Development Regulation Of DNA-binding Transcription Factor Activity Cartilage Development Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Cardiac Neural Crest Cell Development Involved In Heart Development Protein-containing Complex Assembly ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Response To Epidermal Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Cellular Response To Heat Cellular Response To Dopamine Positive Regulation Of Telomere Capping Positive Regulation Of Xenophagy Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Apolipoprotein Binding
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation CD163 mediating an anti-inflammatory response	MAPK3 (ERK1) activation RAF-independent MAPK1/3 activation ISG15 antiviral mechanism Spry regulation of FGF signaling Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RNA Polymerase I Promoter Opening Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Growth hormone receptor signaling
Drugs		Minocycline Dasatinib 4-[5-[2-(1-phenyl-ethylamino)-pyrimidin-4-yl]-1-methyl-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine N-[(3Z)-5-Tert-butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene]-N'-(4-chlorophenyl)urea 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One Inhibitor of P38 Kinase 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea 3-(Benzyloxy)Pyridin-2-Amine 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline Doramapimod 2-Chlorophenol 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole SB220025 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE Triazolopyridine KC706 Talmapimod VX-702 R-1487 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide Neflamapimod N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide PH-797804 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine SD-0006 N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO- 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE Fostamatinib	Sulindac Acetylsalicylic acid Minocycline Arsenic trioxide Purvalanol 5-iodotubercidin Seliciclib Cholecystokinin Ulixertinib
Diseases
GWAS		Foot ulcer in diabetes and neuropathy ( 28672053)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Hodgkin's lymphoma ( 30194254) Multiple sclerosis ( 31604244 24076602) Pubertal anthropometrics ( 23449627) Schizophrenia ( 28991256 25056061 29483656) Tonsillectomy ( 27182965 28928442) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		165 interacting genes: AIMP1 AKT1 ARNT ATF2 BCL2 BCL2L1 BICD1 BMI1 CCDC14 CCDC97 CCND2 CD4 CDC25A CDC25B CDC25C CDK4 CDK6 CDKN2A CDT1 CDX2 CENPC CEP164 COPS5 CREB1 CSNK2A1 CSNK2A2 CSNK2B DAB1 DDIT3 DUSP1 DUSP10 DUSP16 DUSP2 DUSP22 DUSP4 DUSP7 DUSP9 DYRK1B EEA1 EEF1A1 EEF2K EGFR EIF4EBP1 ELK1 ELK3 EPB42 EPHA2 EPS15 ESR1 ETV1 FGFR4 FKBP8 FLNA GADD45A GATA3 GDF15 GMFB GORASP2 GRB2 HDAC3 HIVEP1 HNF4A HSF4 HSPB1 HTRA2 ILKAP INTS6L IRAK1 JDP2 JUN JUNB KAT2A KAT2B KMT2C KRT18 KRT8 LATS2 LIMK1 MAFA MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K10 MAP3K7 MAPK1 MAPK3 MAPK8 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MARS1 MAX MBP MEF2A MEF2C MEF2D MIDEAS MITF MKNK1 MKNK2 MOB3B MUC12 MYC NCOA3 NF2 NFATC1 NFATC4 NFIC NKTR NRL NUP153 PAK6 PHC2 PI4K2B PLA2G4A PLG PML PPARGC1A PPP4R3A PTPN7 RB1 RBSN RELA RET ROBO1 RPL22 RPL41 RPS6KA4 RPS6KA5 S100A9 SCN8A SH2D1A SHC1 SLC9A1 SMAD3 SMAD7 SMARCD3 SNAPIN SPAG9 SPTBN1 SQSTM1 SRPK1 SRSF5 STAT1 STAT4 STK11 STK39 SUPT20H TAB1 TCF20 TFCP2 TLE5 TMEM63B TP53 TRAF6 TSC1 UGT2B10 ULK1 YY1AP1 ZFP36L1 ZNF142 ZNHIT1	186 interacting genes: AKR1C1 AMOT ARRB1 ATP1A1 AURKA BCL2 BCL3 BRAF BTBD10 BUB1 C1QBP CASP8 CASP9 CAV1 CCDC6 CDC23 CDC25C CDC45 CDH1 CDKN2A CEBPB CPXM1 CREBBP CREM CRP CTNND1 CUEDC2 DAPK1 DCC DCP1A DLC1 DUSP1 DUSP10 DUSP3 DUSP4 DUSP5 DUSP6 DUSP9 EGFR ELK1 ELK4 EPOR ESR1 ETS1 ETV1 FBXW7 FCGR2B FKBP2 FOS FOXP2 FRS2 GAB1 GAB2 GATA1 GATA4 GJA1 GMFB GRK2 GTF2I HDAC4 HDAC6 HIF1A HMMR HNF4A HSF1 HSF4 HSPB8 HTRA2 ID2 IER3 INSR IRS1 ITGAV ITGB3 JUN JUND KRT8 KSR2 L3MBTL3 LAMTOR3 LCK LIPE LRPAP1 LRRC4 LYN MAFG MAGEA11 MAGED1 MAP2K1 MAP2K2 MAP2K3 MAP3K14 MAPK14 MAPK8 MAPKAPK2 MAPT MBP MED1 METAP2 MKNK1 MYC MYLK MYOG NAB2 NCKIPSD NGFR NRAS NTRK1 NTRK3 NUP153 NUP58 PAK2 PDE6G PDGFRL PEA15 PFKM PLAT PLCB1 PPARA PPP1CA PPP2CA PRKCD PRKCE PRKCZ PTPN11 PTPN5 PTPN7 PTPRE PTPRR PXN RAB4A RAF1 RALGDS RB1 RCAN1 RET RNF114 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCAND1 SCRIB SMAD2 SNCG SORBS3 SOS1 SOX2 SP1 SPIB SRC SREBF1 SREBF2 STAR STAT3 STAT5A STK11 STMN1 STMN2 STUB1 SULT4A1 SYK SYN1 SYNE2 TAL1 TAL2 TCF3 TGIF1 TH TNFSF11 TOP2B TP53 TRIM54 TSC2 TTYH3 UBE4B UBTF USP21 VDR VPS52 ZC3HC1 ZNF219 ZNF7
Entrez ID		1432	5595
HPRD ID		02619	03479
Ensembl ID		ENSG00000112062	ENSG00000102882
Uniprot IDs		A0A024RD15 B4E0K5 L7RSM2 Q16539	L7RXH5 P27361 Q9BWJ1
PDB IDs		1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBS 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZYJ 1ZZ2 1ZZL 2BAJ 2BAK 2BAL 2BAQ 2FSL 2FSM 2FSO 2FST 2GFS 2I0H 2LGC 2NPQ 2OKR 2ONL 2QD9 2RG5 2RG6 2Y8O 2YIS 2YIW 2YIX 2ZAZ 2ZB0 2ZB1 3BV2 3BV3 3BX5 3C5U 3CTQ 3D7Z 3D83 3DS6 3DT1 3E92 3E93 3FC1 3FI4 3FKL 3FKN 3FKO 3FL4 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN 3FSF 3FSK 3GC7 3GCP 3GCQ 3GCS 3GCU 3GCV 3GFE 3GI3 3HA8 3HEC 3HEG 3HL7 3HLL 3HP2 3HP5 3HRB 3HUB 3HUC 3HV3 3HV4 3HV5 3HV6 3HV7 3HVC 3IPH 3ITZ 3IW5 3IW6 3IW7 3IW8 3K3I 3K3J 3KF7 3KQ7 3L8S 3L8X 3LFA 3LFB 3LFC 3LFD 3LFE 3LFF 3LHJ 3MGY 3MH0 3MH1 3MH2 3MH3 3MPA 3MPT 3MVL 3MVM 3MW1 3NEW 3NNU 3NNV 3NNW 3NNX 3NWW 3O8P 3O8T 3O8U 3OBG 3OBJ 3OC1 3OCG 3OD6 3ODY 3ODZ 3OEF 3PG3 3QUD 3QUE 3RIN 3ROC 3S3I 3S4Q 3U8W 3UVP 3UVQ 3UVR 3ZS5 3ZSG 3ZSH 3ZSI 3ZYA 4A9Y 4AA0 4AA4 4AA5 4AAC 4DLI 4DLJ 4E5A 4E5B 4E6A 4E6C 4E8A 4EH2 4EH3 4EH4 4EH5 4EH6 4EH7 4EH8 4EH9 4EHV 4EWQ 4F9W 4F9Y 4FA2 4GEO 4KIN 4KIP 4KIQ 4L8M 4R3C 4ZTH 5ETA 5ETC 5ETF 5ETI 5ML5 5MTX 5MTY 5MZ3 5N63 5N64 5N65 5N66 5N67 5N68 5O8U 5O8V 5OMG 5OMH 5TBE 5TCO 5WJJ 5XYX 5XYY 6ANL 6HWT 6HWU 6HWV 6M95 6M9L 6OHD 6QDZ 6QE1 6QYX 6RFO 6SFI 6SFJ 6SFK 6SFO 6TCA 6ZWP	2ZOQ 4QTB 6GES
Enriched GO Terms of Interacting Partners?
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