CRYAB and EPB41

Data Source:
HPRD (two hybrid)

		CRYAB	EPB41
Description		crystallin alpha B	erythrocyte membrane protein band 4.1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cell Surface Postsynaptic Density Microtubule Cytoskeleton Z Disc Axon M Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Extracellular Exosome Synaptic Membrane Cardiac Myofibril	Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle Cell Cortex Region
	Molecular Function	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Protein C-terminus Binding Spectrin Binding Protein N-terminus Binding Phosphoprotein Binding
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Multicellular Organism Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process	Cell Cycle Regulation Of Cell Shape Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Protein Binding Cell Division Regulation Of Calcium Ion Transport Protein-containing Complex Assembly Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex
Pathways		HSF1-dependent transactivation	Neurexins and neuroligins
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy	Hereditary elliptocytosis (HE)
GWAS		Birth weight ( 31043758) PR interval ( 32439900)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		54 interacting genes: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYAA2 CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	39 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		1410	2035
HPRD ID		00428	00558
Ensembl ID		ENSG00000109846	ENSG00000159023
Uniprot IDs		A0A024R3B9 P02511 V9HW27	A0A2R8Y7Y3 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs		2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9	1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?
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