EPB41 and MACROD1

Data Source:
HPRD (two hybrid)

		EPB41	MACROD1
Description		erythrocyte membrane protein band 4.1	mono-ADP ribosylhydrolase 1
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle Cell Cortex Region	Nucleus Nucleoplasm
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Protein C-terminus Binding Spectrin Binding Protein N-terminus Binding Phosphoprotein Binding	Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	Cell Cycle Regulation Of Cell Shape Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Protein Binding Cell Division Regulation Of Calcium Ion Transport Protein-containing Complex Assembly Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex	Cellular Response To DNA Damage Stimulus Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways		Neurexins and neuroligins
Drugs
Diseases		Hereditary elliptocytosis (HE)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)	Bipolar disorder ( 31043756) Body mass index ( 25673413) Fruit consumption ( 32066663) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 25673412) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Serum uric acid levels ( 32514006) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		39 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10	4 interacting genes: EPB41 IKBKG KPNA1 UXT
Entrez ID		2035	28992
HPRD ID		00558	17448
Ensembl ID		ENSG00000159023	ENSG00000133315
Uniprot IDs		A0A2R8Y7Y3 P11171 Q1WWM3 Q29RX4 Q59F12	A0A6Q8PH91 Q9BQ69
PDB IDs		1GG3 2RQ1 3QIJ	2X47
Enriched GO Terms of Interacting Partners?
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