CRYAB and FGF2

Data Source:
BioGRID (unspecified method)

		CRYAB	FGF2
Description		crystallin alpha B	fibroblast growth factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cell Surface Postsynaptic Density Microtubule Cytoskeleton Z Disc Axon M Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Extracellular Exosome Synaptic Membrane Cardiac Myofibril	Extracellular Region Extracellular Space Nucleus Cytoplasm
	Molecular Function	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding	Fibroblast Growth Factor Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Chemokine Binding Nuclear Receptor Coactivator Activity Chemoattractant Activity Identical Protein Binding Receptor-receptor Interaction
	Biological Process	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Multicellular Organism Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Regulation Of Cellular Response To Heat Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process	MAPK Cascade Activation Of MAPK Activity Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Chemotaxis Signal Transduction Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Cytokine-mediated Signaling Pathway Cell Differentiation Extracellular Matrix Organization Hyaluronan Catabolic Process Lung Development Regulation Of Cell Migration Inositol Phosphate Biosynthetic Process Somatic Stem Cell Population Maintenance Paracrine Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cell Death Chondroblast Differentiation Negative Regulation Of Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Stem Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		HSF1-dependent transactivation	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM Signaling by FGFR3 point mutants in cancer
Drugs			Sucralfate Pentosan polysulfate Sirolimus Heparin 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid ABT-510
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Birth weight ( 31043758) PR interval ( 32439900)	Acne (severe) ( 30542056) Blood protein levels ( 28240269) Body mass index ( 25673413) Irritable bowel syndrome ( 24797007) Mosquito bite size ( 28199695) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		54 interacting genes: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYAA2 CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA	31 interacting genes: API5 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 GPC3 GPC4 HSPG2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 SNTG1 THBS1 VTN
Entrez ID		1410	2247
HPRD ID		00428	00622
Ensembl ID		ENSG00000109846	ENSG00000138685
Uniprot IDs		A0A024R3B9 P02511 V9HW27	P09038
PDB IDs		2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9	1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 2M49 4FGF 4OEE 4OEF 4OEG 5X1O 6L4O
Enriched GO Terms of Interacting Partners?
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