MTPN and CAPZB

Data Source:
HPRD (in vivo)

		MTPN	CAPZB
Description		myotrophin	capping actin protein of muscle Z-line subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol F-actin Capping Protein Complex Axon Perinuclear Region Of Cytoplasm	Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Sarcomere Extracellular Exosome WASH Complex
	Molecular Function	Sequence-specific DNA Binding	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Regulation Of Translation Catecholamine Metabolic Process Regulation Of Cell Size Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Striated Muscle Tissue Development Cerebellar Granule Cell Differentiation Neuron Differentiation Positive Regulation Of Cell Growth Skeletal Muscle Tissue Regeneration Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Cellular Response To Mechanical Stimulus Regulation Of Barbed-end Actin Filament Capping	Cell Morphogenesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Blood Coagulation Regulation Of Lamellipodium Assembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Barbed-end Actin Filament Capping Negative Regulation Of Filopodium Assembly
Pathways			MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Mean platelet volume ( 32888494) Platelet count ( 27863252) Platelet distribution width ( 32888494 27863252) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease and psoriasis ( 22482804) Heel bone mineral density ( 30598549) Height ( 28552196) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Lead levels in blood ( 25820613) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Serum thyroid-stimulating hormone levels ( 24852370) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Thyroid volume ( 21565293)
Interacting Genes		5 interacting genes: CAPZB MAPK1 NFKB1 REL RELA	9 interacting genes: BCCIP CDC42 HSPA8 MRPL20 MTPN PTN RPP14 SIRPA VHL
Entrez ID		136319	832
HPRD ID		07574	11872
Ensembl ID		ENSG00000105887	ENSG00000077549
Uniprot IDs		P58546 Q69YG1	A0A384MR50 B1AK85 B1AK88 B4DWA6 P47756 Q7L4N0
PDB IDs		3AAA
Enriched GO Terms of Interacting Partners?
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