PPARGC1B and ZNF212

Data Source:
BioGRID (two hybrid)

		PPARGC1B	ZNF212
Description		PPARG coactivator 1 beta	zinc finger protein 212
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Cytosol Mediator Complex	Nucleoplasm
	Molecular Function	Transcription Coregulator Activity RNA Binding Transcription Factor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity AF-2 Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Ossification Regulation Of Transcription, DNA-templated Mitochondrial Transcription Actin Filament Organization Positive Regulation Of Alkaline Phosphatase Activity Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Positive Regulation Of Phosphorylation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Response To Glucocorticoid Response To CAMP Bone Trabecula Formation Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	Generic Transcription Pathway
Drugs		Amiodarone
Diseases
GWAS		Age spots ( 29895819) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) Cutaneous malignant melanoma ( 32341527) Deep white matter hyperintensities ( 32517579) Electrocardiographic traits ( 32602732) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 29895819) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obesity-related traits ( 23251661) Tanning ( 19340012) Vitiligo ( 27723757)	Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: AKT1 ESR1 ESRRG HCFC1 HNF4A PPARA SRC THRB ZBTB9 ZFP64 ZNF200 ZNF212 ZNF513	30 interacting genes: - ATF3 ATF4 BYSL CREB3L2 CSK DPF2 DUSP6 FAM90A1 FHL2 GAS8 GNL1 GYS1 HBP1 KANK2 MLH1 NFKBIA NKX2-3 PPARGC1B PRKAA2 PTP4A1 RND1 SAP30BP SF3A3 SUV39H2 ZNF3 ZNF331 ZNF408 ZNF783 ZZZ3
Entrez ID		133522	7988
HPRD ID		10594	03859
Ensembl ID		ENSG00000155846	ENSG00000170260
Uniprot IDs		B7ZM40 Q86YN6	A0A090N8N3 B3KQE6 Q9UDV6
PDB IDs		3SP6 6D0Y
Enriched GO Terms of Interacting Partners?
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