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COL8A1 and CCN3
Data Source:
BioGRID
(two hybrid)
COL8A1
CCN3
Description
collagen type VIII alpha 1 chain
cellular communication network factor 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Type VIII Trimer
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Extracellular Region
Cytoplasm
Gap Junction
Axon
Dendrite
Extracellular Matrix
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Notch Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Growth Factor Activity
Heparin Binding
Biological Process
Angiogenesis
Cell Adhesion
Positive Regulation Of Cell-substrate Adhesion
Extracellular Matrix Organization
Endodermal Cell Differentiation
Camera-type Eye Morphogenesis
Epithelial Cell Proliferation
Angiogenesis
Chondrocyte Differentiation
Cell Adhesion
Signal Transduction
Regulation Of Gene Expression
Fibroblast Migration
Negative Regulation Of Myotube Differentiation
Smooth Muscle Cell Migration
Negative Regulation Of Cell Growth
Cell Adhesion Mediated By Integrin
Endothelial Cell Chemotaxis
Type B Pancreatic Cell Proliferation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Insulin Secretion
Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Cell Death
Hematopoietic Stem Cell Homeostasis
Endothelial Cell-cell Adhesion
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Chondrocyte Proliferation
Negative Regulation Of Sensory Perception Of Pain
Bone Regeneration
Pathways
Collagen degradation
Collagen degradation
Collagen biosynthesis and modifying enzymes
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Collagen chain trimerization
Drugs
Insulin pork
Diseases
GWAS
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385826
23455636
)
Axial length (
24144296
)
Childhood ear infection (
27182965
)
Cleft lip with or without cleft palate (
28054174
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Optic cup area (
25631615
31798171
28073927
)
Optic disc area (
31798171
28073927
)
Refractive error (
32231278
)
Superior frontal gyrus grey matter volume (
25335168
)
Vertical cup-disc ratio (
31798171
25241763
28073927
)
Interacting Genes
78 interacting genes:
ADAMTSL4
ARMC5
BPIFA1
C11orf1
C19orf54
C22orf39
C9orf24
CCN3
CEP55
CIDEB
COL8A2
CREB5
CYSRT1
DPEP2NB
EFEMP2
FAM86C1P
FBLN2
FBXO34
FRS3
GLRX3
GSC2
HOXA1
INCA1
ITGA1
ITGA2
KLHL12
KLHL20
KPRP
KRT37
KRT40
KRT82
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP12-3
KRTAP13-1
KRTAP13-3
KRTAP19-2
KRTAP19-5
KRTAP19-7
KRTAP26-1
KRTAP3-2
KRTAP4-12
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
LIMS1
MAJIN
NADSYN1
NBPF19
NOTCH2NLA
OTX1
PLSCR3
POF1B
POU4F2
PPARA
RBPMS
REL
RGS20
RHBDD2
SLC35A2
SP4
SPATA8
SPRY4
SSC4D
TRIM35
UBQLN2
UBQLN4
VAC14
WFDC5
YPEL3
ZNF774
ZNHIT1
29 interacting genes:
ADSL
ANKRD11
APOL6
C11orf87
CCN2
CDKN1A
COL8A1
DLL1
FAM90A1
FBLN1
FN1
FRS3
GJA1
HOXA1
IGF1
IGF2
INS
ITGAV
KRTAP5-6
LCE1A
LCE3D
NID2
NOTCH1
POLR2L
POU4F2
RECK
S100A4
TNIP3
ZNF330
Entrez ID
1295
4856
HPRD ID
00372
01291
Ensembl ID
ENSG00000144810
ENSG00000136999
Uniprot IDs
P27658
A0A024R9J4
P48745
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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