COL8A1 and KRTAP19-2

Data Source:
BioGRID (two hybrid)

		COL8A1	KRTAP19-2
Description		collagen type VIII alpha 1 chain	keratin associated protein 19-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Cytosol Intermediate Filament
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protein Binding
	Biological Process	Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation	Keratinization
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Keratinization
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Refractive error ( 32231278) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927)
Interacting Genes		78 interacting genes: ADAMTSL4 ARMC5 BPIFA1 C11orf1 C19orf54 C22orf39 C9orf24 CCN3 CEP55 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1	46 interacting genes: ADAMTSL4 ANAPC11 ATN1 C11orf16 CHRD COL8A1 CREB5 CYSRT1 EFEMP1 ETHE1 FBLN1 FOXD2 FOXH1 GNE HOXC8 HSD3B7 KPRP KRTAP12-2 KRTAP12-4 KRTAP3-3 KRTAP4-12 KRTAP6-3 KRTAP9-3 LCE2D MEIS2 MGAT5B MKRN3 NTAQ1 OLIG3 OTX1 PCSK5 PIGS POU4F2 RHBG SLC12A4 SLC15A3 SMARCC1 SNRPC SPAG8 TEKT4 TENT5D TFAP2D VENTX VGLL3 VWC2L ZIC1
Entrez ID		1295	337969
HPRD ID		00372	11206
Ensembl ID		ENSG00000144810	ENSG00000186965
Uniprot IDs		P27658	Q3LHN2
PDB IDs
Enriched GO Terms of Interacting Partners?
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