CCN3 and ADSL

Data Source:
BioGRID (two hybrid)

		CCN3	ADSL
Description		cellular communication network factor 3	adenylosuccinate lyase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Gap Junction Axon Dendrite Extracellular Matrix Neuronal Cell Body Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix	Cytosol Protein-containing Complex
	Molecular Function	Notch Binding Integrin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Activity Heparin Binding	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) Activity Identical Protein Binding (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) Activity
	Biological Process	Angiogenesis Chondrocyte Differentiation Cell Adhesion Signal Transduction Regulation Of Gene Expression Fibroblast Migration Negative Regulation Of Myotube Differentiation Smooth Muscle Cell Migration Negative Regulation Of Cell Growth Cell Adhesion Mediated By Integrin Endothelial Cell Chemotaxis Type B Pancreatic Cell Proliferation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Insulin Secretion Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Death Hematopoietic Stem Cell Homeostasis Endothelial Cell-cell Adhesion Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Sensory Perception Of Pain Bone Regeneration	Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process 'de Novo' AMP Biosynthetic Process
Pathways			Purine ribonucleoside monophosphate biosynthesis
Drugs		Insulin pork
Diseases			Adenylosuccinate lyase deficiency
GWAS			Body mass index ( 26426971) Height ( 19570815) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		29 interacting genes: ADSL ANKRD11 APOL6 C11orf87 CCN2 CDKN1A COL8A1 DLL1 FAM90A1 FBLN1 FN1 FRS3 GJA1 HOXA1 IGF1 IGF2 INS ITGAV KRTAP5-6 LCE1A LCE3D NID2 NOTCH1 POLR2L POU4F2 RECK S100A4 TNIP3 ZNF330	3 interacting genes: CALCOCO2 CCN3 REL
Entrez ID		4856	158
HPRD ID		01291	00049
Ensembl ID		ENSG00000136999	ENSG00000239900
Uniprot IDs		A0A024R9J4 P48745	P30566 X5D7W4 X5D8S6
PDB IDs			2J91 2VD6 4FFX 4FLC
Enriched GO Terms of Interacting Partners?
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