COL4A1 and HABP2

Data Source:
HPRD (in vivo)

		COL4A1	HABP2
Description		collagen type IV alpha 1 chain	hyaluronan binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Platelet-derived Growth Factor Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Glycosaminoglycan Binding Peptidase Activity
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Brain Development Neuromuscular Junction Development Extracellular Matrix Organization Epithelial Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Blood Vessel Morphogenesis Retinal Blood Vessel Morphogenesis Renal Tubule Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization	Proteolysis Cell Adhesion
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization
Drugs			Hyaluronic acid
Diseases		Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
GWAS		Age-related nuclear cataracts ( 24951543) Arterial stiffness ( 20031579) Behavioral disturbance or psychiatric symptoms and prion disease ( 25897833) Coronary artery disease ( 32469254 29212778 24262325 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) ( 30920136) Intraocular pressure ( 29785010 31959993) Lateral ventricle volume ( 31530798) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494 27863252) Myocardial infarction ( 26343387) Night sleep phenotypes ( 27126917) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Obesity-related traits ( 23251661) Peripheral artery disease ( 31285632) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Stroke ( 30383316 29531354) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 28552196)	Blood protein levels ( 29875488) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cardiac troponin-I levels ( 31014085) Central corneal thickness ( 32528159 29760442) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Heel bone mineral density ( 28869591) Ischemic stroke ( 26732560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Plasma factor VII activating protease levels ( 30070759) Urate levels ( 31578528) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		27 interacting genes: ACHE APCS APP BMP3 CD93 COL4A2 COL7A1 DCN DISC1 FBLN2 FN1 HABP2 MAG MATN2 MMP9 NID1 NID2 OSM PDGFA PDGFB SAA1 SAA2 SAA4 SERPINE2 SMAD1 TGFBI THBS1	7 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 KNG1
Entrez ID		1282	3026
HPRD ID		00359	04890
Ensembl ID		ENSG00000187498	ENSG00000148702
Uniprot IDs		A5PKV2 P02462	Q14520
PDB IDs		1LI1 5NAX 5NAY 6MPX
Enriched GO Terms of Interacting Partners?
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