HABP2 and COL4A4

Data Source:
HPRD (in vivo)

		HABP2	COL4A4
Description		hyaluronan binding protein 2	collagen type IV alpha 4 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Glycosaminoglycan Binding Peptidase Activity	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Proteolysis Cell Adhesion	Extracellular Matrix Organization Glomerular Basement Membrane Development
Pathways			Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		Hyaluronic acid	TRC093
Diseases			Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Blood protein levels ( 29875488) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cardiac troponin-I levels ( 31014085) Central corneal thickness ( 32528159 29760442) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Heel bone mineral density ( 28869591) Ischemic stroke ( 26732560) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Plasma factor VII activating protease levels ( 30070759) Urate levels ( 31578528) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Birth weight ( 31043758) Body mass index ( 28270201 25673413) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		7 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 KNG1	13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI
Entrez ID		3026	1286
HPRD ID		04890	00360
Ensembl ID		ENSG00000148702	ENSG00000081052
Uniprot IDs		Q14520	P53420
PDB IDs			5NB1
Enriched GO Terms of Interacting Partners?
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