TNFAIP8L1 and MED4

Data Source:
BioGRID (two hybrid)

		TNFAIP8L1	MED4
Description		TNF alpha induced protein 8 like 1	mediator complex subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Identical Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of TOR Signaling Regulation Of Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		PI Metabolism	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		12 interacting genes: ANKRD36B APP CAVIN1 DVL3 EVI5 MED4 PLEKHF2 PSME3 RPL9 SNRPA STAC3 ZRSR2	41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 SYCE2 TLE5 TNFAIP8 TNFAIP8L1 TXLNA TXLNB USHBP1 WDTC1
Entrez ID		126282	29079
HPRD ID		11314	16145
Ensembl ID		ENSG00000185361	ENSG00000136146
Uniprot IDs		Q8WVP5	A0A024RDY7 Q9NPJ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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