MED4 and SGF29

Data Source:
BioGRID (two hybrid)

		MED4	SGF29
Description		mediator complex subunit 4	SAGA complex associated factor 29
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	SAGA Complex Ada2/Gcn5/Ada3 Transcription Activator Complex SAGA-type Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Protein Binding Enzyme Binding Methylated Histone Binding Protein N-terminus Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Histone Acetylation Histone H3 Acetylation Establishment Of Protein Localization To Chromatin
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	HATs acetylate histones
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 SYCE2 TLE5 TNFAIP8 TNFAIP8L1 TXLNA TXLNB USHBP1 WDTC1	30 interacting genes: BECN1 C20orf202 CCDC102B CCDC158 CLHC1 DBF4B H3-4 KNSTRN KRT13 KRT15 KRT16 KRT19 KRT24 KRT27 KRT33B LNX1 LZTS1 MED11 MED4 MYF5 NDC80 PROSER3 RINT1 SYCE3 SYNPO TADA3 TCF4 TEX12 TFIP11 TRAF3IP1
Entrez ID		29079	112869
HPRD ID		16145	13996
Ensembl ID		ENSG00000136146	ENSG00000176476
Uniprot IDs		A0A024RDY7 Q9NPJ6	Q96ES7
PDB IDs			3LX7 3ME9 3MEA 3MET 3MEU 3MEV 3MEW 5C0M
Enriched GO Terms of Interacting Partners?
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