MED4 and WDTC1

Data Source:
BioGRID (two hybrid)

		MED4	WDTC1
Description		mediator complex subunit 4	WD and tetratricopeptide repeats 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Nucleoplasm Cytoplasm Cytosol Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	Enzyme Inhibitor Activity Protein Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Glucose Metabolic Process Regulation Of Cell Size Protein Ubiquitination Cellular Response To Insulin Stimulus Multicellular Organism Growth Negative Regulation Of Catalytic Activity Post-translational Protein Modification Negative Regulation Of Fatty Acid Biosynthetic Process Cellular Chemical Homeostasis
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	Neddylation
Drugs
Diseases
GWAS		Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 SYCE2 TLE5 TNFAIP8 TNFAIP8L1 TXLNA TXLNB USHBP1 WDTC1	3 interacting genes: DDB1 MED23 MED4
Entrez ID		29079	23038
HPRD ID		16145	10307
Ensembl ID		ENSG00000136146	ENSG00000142784
Uniprot IDs		A0A024RDY7 Q9NPJ6	Q8N5D0
PDB IDs			3I7N
Enriched GO Terms of Interacting Partners?
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