HEXIM2 and CACNB2

Data Source:
BioGRID (two hybrid)

		HEXIM2	CACNB2
Description		HEXIM P-TEFb complex subunit 2	calcium voltage-gated channel auxiliary subunit beta 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Photoreceptor Ribbon Synapse Presynapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Actin Filament Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated	Chemical Synaptic Transmission Neuromuscular Junction Development Visual Perception Positive Regulation Of Calcium Ion Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Depolarization During AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways			Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Nicardipine Magnesium sulfate Levomenthol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Nilvadipine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Brugada syndrome (BRS)
GWAS		Asthma ( 31959851 31619474) Brain morphology (MOSTest) ( 32665545) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21909110) Body mass index ( 28892062) Brain volume in infants (grey matter) ( 28763065) Cadmium levels ( 26025379) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 19430479 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertension ( 31879980 19430479 21909115) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (HVA/MHPG ratio) ( 23319000) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Quantitative traits ( 19197348) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Small vessel stroke ( 26732560) Systolic blood pressure ( 28135244 19430479 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		49 interacting genes: ADAMTSL4 AHCYL1 AP2M1 CACNB2 CCDC33 CCNT1 CDK9 CFP CTIF DBF4B EGFL7 FAM161A GAS8 GATA1 HEXIM1 HOXA1 HSF2BP IHO1 KPNA3 KPRP KRTAP13-3 LNX1 MEOX2 PICK1 PIM1 PIN1 PRDM14 PSMA1 RNPS1 SAXO1 SDCBP SPRED1 SPRY1 SPRY2 TADA3 TCF12 TERF1 TERF2 TLE5 TNFAIP1 TRIM14 YPEL3 ZNF250 ZNF426 ZNF500 ZNF558 ZNF655 ZNF699 ZNF789	6 interacting genes: CTBP2 HEXIM2 PRKACA PRMT5 REM1 TMEM174
Entrez ID		124790	783
HPRD ID		08129	02473
Ensembl ID		ENSG00000168517	ENSG00000165995
Uniprot IDs		Q96MH2	A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1
PDB IDs
Enriched GO Terms of Interacting Partners?
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