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HEXIM2 and CCNT1
Data Source:
HPRD
(two hybrid)
HEXIM2
CCNT1
Description
HEXIM P-TEFb complex subunit 2
cyclin T1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Speck
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Cyclin/CDK Positive Transcription Elongation Factor Complex
P-TEFb Complex
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
SnRNA Binding
Identical Protein Binding
7SK SnRNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Chromatin Binding
Protein Binding
Transcription Factor Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
RNA Polymerase Binding
7SK SnRNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Protein Phosphorylation
Cell Cycle
Viral Process
Positive Regulation Of DNA-templated Transcription, Elongation
SnRNA Transcription By RNA Polymerase II
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Cell Division
Negative Regulation Of MRNA Polyadenylation
Pathways
Formation of RNA Pol II elongation complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Interactions of Tat with host cellular proteins
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
Estrogen-dependent gene expression
Drugs
Diseases
GWAS
Asthma (
31959851
31619474
)
Brain morphology (MOSTest) (
32665545
)
Craniofacial microsomia (
26853712
)
Male-pattern baldness (
28196072
)
Systolic blood pressure (
19430483
)
Clozapine-induced agranulocytosis (
25187353
)
Interacting Genes
49 interacting genes:
ADAMTSL4
AHCYL1
AP2M1
CACNB2
CCDC33
CCNT1
CDK9
CFP
CTIF
DBF4B
EGFL7
FAM161A
GAS8
GATA1
HEXIM1
HOXA1
HSF2BP
IHO1
KPNA3
KPRP
KRTAP13-3
LNX1
MEOX2
PICK1
PIM1
PIN1
PRDM14
PSMA1
RNPS1
SAXO1
SDCBP
SPRED1
SPRY1
SPRY2
TADA3
TCF12
TERF1
TERF2
TLE5
TNFAIP1
TRIM14
YPEL3
ZNF250
ZNF426
ZNF500
ZNF558
ZNF655
ZNF699
ZNF789
26 interacting genes:
AFF4
AHR
BRD4
CDK9
CEBPB
ESR1
GRIPAP1
GRN
GTF2F1
HEXIM1
HEXIM2
HIC2
HTATSF1
HTN1
KAT2B
MDFIC
MYC
NCOA2
NUFIP1
PML
POLR2A
PRKCI
PURA
RN7SK
SKP2
SUPT5H
Entrez ID
124790
904
HPRD ID
08129
03938
Ensembl ID
ENSG00000168517
ENSG00000129315
Uniprot IDs
Q96MH2
A8K4M5
O60563
PDB IDs
2PK2
3BLH
3BLQ
3BLR
3LQ5
3MI9
3MIA
3MY1
3TN8
3TNH
3TNI
4BCF
4BCG
4BCH
4BCI
4BCJ
4EC8
4EC9
4IMY
4OGR
4OR5
5L1Z
6CYT
6GZH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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