CCR5 and TXK

Data Source:
HPRD (in vivo)

		CCR5	TXK
Description		C-C motif chemokine receptor 5	TXK tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Virus Receptor Activity Actin Binding Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding Identical Protein Binding Chemokine (C-C Motif) Ligand 5 Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Dendritic Cell Chemotaxis Calcium Ion Transport Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Fusion Of Virus Membrane With Host Plasma Membrane Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway Response To Cholesterol Cellular Response To Lipopolysaccharide	Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Binding and entry of HIV virion Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		Maraviroc AMD-070 CCR5 mAb Leronlimab Aplaviroc Vicriviroc Ibalizumab INCB-9471	Fostamatinib Zanubrutinib
Diseases
GWAS		Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 20190752) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Type 1 diabetes ( 25751624) Ulcerative colitis ( 26192919 28067908)	Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)
Interacting Genes		43 interacting genes: AFP ARL6IP5 ARRB1 CCL11 CCL13 CCL14 CCL16 CCL2 CCL3 CCL3L1 CCL3L3 CCL4 CCL5 CCL7 CCL8 CD4 CST9L CTBP2 CXCR4 DNM2 EMP1 ETV5 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GRK2 GRK3 IL24 JAK1 JAK2 LCK ORM1 PRAF2 PSMA5 PTK2 PTK2B SLC20A2 STAT1 STAT3 STAT5A TXK	38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835
Entrez ID		1234	7294
HPRD ID		03223	02505
Ensembl ID		ENSG00000160791	ENSG00000074966
Uniprot IDs		P51681 Q38L21	P42681
PDB IDs		1ND8 1NE0 1OPN 1OPT 1OPW 2L87 2MZX 2RLL 2RRS 4MBS 5UIW 5YD3 5YD4 5YD5 5YY4 6FGP 6MEO 6MET	2DM0
Enriched GO Terms of Interacting Partners?
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