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CCR5 and CCL11
Data Source:
HPRD
(in vitro, in vivo)
CCR5
CCL11
Description
C-C motif chemokine receptor 5
C-C motif chemokine ligand 11
Image
GO Annotations
Cellular Component
Cytoplasm
Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Extracellular Region
Extracellular Space
Molecular Function
Virus Receptor Activity
Actin Binding
Phosphatidylinositol Phospholipase C Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Identical Protein Binding
Chemokine (C-C Motif) Ligand 5 Binding
Protein Binding
Chemokine Activity
CCR3 Chemokine Receptor Binding
Protein Dimerization Activity
Receptor Ligand Activity
CCR Chemokine Receptor Binding
Biological Process
MAPK Cascade
Dendritic Cell Chemotaxis
Calcium Ion Transport
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Fusion Of Virus Membrane With Host Plasma Membrane
Cytokine-mediated Signaling Pathway
Calcium-mediated Signaling
Signaling
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Response To Cholesterol
Cellular Response To Lipopolysaccharide
Positive Regulation Of Endothelial Cell Proliferation
Chronic Inflammatory Response
Monocyte Chemotaxis
Mast Cell Chemotaxis
Protein Phosphorylation
Cellular Calcium Ion Homeostasis
Chemotaxis
Inflammatory Response
Cytoskeleton Organization
Actin Filament Organization
Cell Adhesion
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Learning Or Memory
Regulation Of Cell Shape
Response To Radiation
Response To Virus
Cytokine-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Actin Filament Polymerization
Response To Interleukin-13
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Negative Regulation Of Neurogenesis
Branching Involved In Mammary Gland Duct Morphogenesis
Mammary Duct Terminal End Bud Growth
Chemokine-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-4
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Modulation Of Age-related Behavioral Decline
Pathways
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Chemokine receptors bind chemokines
Interleukin-4 and Interleukin-13 signaling
Drugs
Maraviroc
AMD-070
CCR5 mAb
Leronlimab
Aplaviroc
Vicriviroc
Ibalizumab
INCB-9471
CAT-213
Diseases
GWAS
Blood protein levels (
28240269
)
Blood protein levels in cardiovascular risk (
28369058
)
Celiac disease (
20190752
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Type 1 diabetes (
25751624
)
Ulcerative colitis (
26192919
28067908
)
Crohn's disease (
28067908
22412388
)
Gut microbiota (functional units) (
27694959
)
Inflammatory bowel disease (
28067908
23128233
)
Interacting Genes
43 interacting genes:
AFP
ARL6IP5
ARRB1
CCL11
CCL13
CCL14
CCL16
CCL2
CCL3
CCL3L1
CCL3L3
CCL4
CCL5
CCL7
CCL8
CD4
CST9L
CTBP2
CXCR4
DNM2
EMP1
ETV5
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GRK2
GRK3
IL24
JAK1
JAK2
LCK
ORM1
PRAF2
PSMA5
PTK2
PTK2B
SLC20A2
STAT1
STAT3
STAT5A
TXK
29 interacting genes:
ACKR2
ACKR4
CCL13
CCL14
CCL18
CCL2
CCL26
CCL27
CCL28
CCL5
CCL8
CCR3
CCR5
CXCL1
CXCL10
CXCL11
CXCL12
CXCL14
CXCL2
CXCL3
CXCL5
CXCL6
CXCL9
DPP4
NUDT3
PF4
PF4V1
TPI1
XCL1
Entrez ID
1234
6356
HPRD ID
03223
03098
Ensembl ID
ENSG00000160791
ENSG00000172156
Uniprot IDs
P51681
Q38L21
P51671
Q6I9T4
PDB IDs
1ND8
1NE0
1OPN
1OPT
1OPW
2L87
2MZX
2RLL
2RRS
4MBS
5UIW
5YD3
5YD4
5YD5
5YY4
6FGP
6MEO
6MET
1EOT
2EOT
2MPM
Enriched GO Terms of Interacting Partners
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