CCL11 and ACKR4

Data Source:
HPRD (in vitro)

		CCL11	ACKR4
Description		C-C motif chemokine ligand 11	atypical chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling	Chemokine receptors bind chemokines
Drugs		CAT-213
Diseases
GWAS		Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		29 interacting genes: ACKR2 ACKR4 CCL13 CCL14 CCL18 CCL2 CCL26 CCL27 CCL28 CCL5 CCL8 CCR3 CCR5 CXCL1 CXCL10 CXCL11 CXCL12 CXCL14 CXCL2 CXCL3 CXCL5 CXCL6 CXCL9 DPP4 NUDT3 PF4 PF4V1 TPI1 XCL1	11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6356	51554
HPRD ID		03098	07298
Ensembl ID		ENSG00000172156	ENSG00000129048
Uniprot IDs		P51671 Q6I9T4	Q9NPB9
PDB IDs		1EOT 2EOT 2MPM
Enriched GO Terms of Interacting Partners?
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