GRIN3A and PTPA

Data Source:
BioGRID (two hybrid)

		GRIN3A	PTPA
Description		glutamate ionotropic receptor NMDA type subunit 3A	protein phosphatase 2 phosphatase activator
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Integral Component Of Membrane NMDA Selective Glutamate Receptor Complex Neuron Projection Neuronal Cell Body Synapse Postsynaptic Membrane Glutamatergic Synapse	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome
	Molecular Function	NMDA Glutamate Receptor Activity Calcium Channel Activity Protein Binding Ligand-gated Ion Channel Activity Glycine Binding Signaling Receptor Activity Identical Protein Binding Protein Phosphatase 2A Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity ATPase Activity Protein Phosphatase Regulator Activity Protein Homodimerization Activity Protein Phosphatase 2A Binding
	Biological Process	Calcium Ion Transport Dendrite Development Ionotropic Glutamate Receptor Signaling Pathway Response To Ethanol Regulation Of Postsynaptic Membrane Potential Prepulse Inhibition Calcium Ion Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis	Protein Peptidyl-prolyl Isomerization Mitotic Spindle Organization Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity
Pathways		Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Profenamine Secobarbital Dextromethorphan Acamprosate Procaine Donepezil Guaifenesin Ethanol Amantadine Memantine Halothane Orphenadrine Phenobarbital Ketamine Aripiprazole Tenocyclidine Rolicyclidine Prasterone Phencyclidine Milnacipran Neramexane Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Asthma ( 27611488) Coronary artery aneurysm in Kawasaki disease ( 26434682) Coronary artery calcification ( 23870195) Glucocorticoid-induced osteonecrosis ( 26265699) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Glucocorticoid-induced osteonecrosis (time dependent analysis) ( 26265699) Obesity-related traits ( 23251661) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Response to fenofibrate (triglyceride levels) ( 27002377) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		6 interacting genes: DLG4 DYNLL1 GRIN1 GRIN2A GRIN2B PTPA	28 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SPG21 SRC SULT4A1
Entrez ID		116443	5524
HPRD ID		09443	02858
Ensembl ID		ENSG00000198785	ENSG00000119383
Uniprot IDs		Q8TCU5	B4DZF8 F6WIT2 Q15257
PDB IDs			2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?
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