PTPA and DTD1

Data Source:
BioGRID (enzymatic study)

		PTPA	DTD1
Description		protein phosphatase 2 phosphatase activator	D-aminoacyl-tRNA deacylase 1
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity ATPase Activity Protein Phosphatase Regulator Activity Protein Homodimerization Activity Protein Phosphatase 2A Binding	TRNA Binding DNA Binding Metal Ion Binding D-tyrosyl-tRNA(Tyr) Deacylase Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Mitotic Spindle Organization Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity	DNA Replication TRNA Metabolic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30679032) Bitter alcoholic beverage consumption ( 31046077) C-reactive protein (red blood cell fatty acid level interaction) ( 28820441) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		28 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SPG21 SRC SULT4A1	4 interacting genes: CDC7 CSNK2A1 NR3C1 PTPA
Entrez ID		5524	92675
HPRD ID		02858	13631
Ensembl ID		ENSG00000119383	ENSG00000125821
Uniprot IDs		B4DZF8 F6WIT2 Q15257	A0A2R8Y6X2 Q8TEA8
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3	2OKV
Enriched GO Terms of Interacting Partners?
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