PTPA and EIF4EBP1

Data Source:
BioGRID (enzymatic study)

		PTPA	EIF4EBP1
Description		protein phosphatase 2 phosphatase activator	eukaryotic translation initiation factor 4E binding protein 1
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GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol Protein-containing Complex Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity ATPase Activity Protein Phosphatase Regulator Activity Protein Homodimerization Activity Protein Phosphatase 2A Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity Protein Phosphatase 2A Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Mitotic Spindle Organization Negative Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Lung Development Negative Regulation Of Protein-containing Complex Assembly TOR Signaling Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation Cellular Response To Hypoxia Response To Amino Acid Starvation
Pathways			mTORC1-mediated signalling Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Drugs
Diseases
GWAS			Menopause (age at onset) ( 29773799)
Interacting Genes		28 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SPG21 SRC SULT4A1	38 interacting genes: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 DDIT4L EIF4E EIF4E1B EIF4E2 GSK3B IRAK4 LATS1 LMO2 LRRK2 MAPK1 MAPK14 MAPKAPK5 MEOX1 MLST8 MTOR MVD PICK1 POU6F2 PPP2CA PRKCA PRKDC PTPA REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4 ZNF655
Entrez ID		5524	1978
HPRD ID		02858	03746
Ensembl ID		ENSG00000119383	ENSG00000187840
Uniprot IDs		B4DZF8 F6WIT2 Q15257	Q13541
PDB IDs		2G62 2HV6 2HV7 2IXM 4LAC 4NY3	1EJ4 1EJH 1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X 4UED 5BXV 5EKV 5NVN 5WBJ 6BCU 6BCX
Enriched GO Terms of Interacting Partners?
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