STK38 and TRIM25

Data Source:
BioGRID (affinity chromatography technology, pull down)

		STK38	TRIM25
Description		serine/threonine kinase 38	tripartite motif containing 25
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transcription Coactivator Activity RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Regulation Of Protein Localization Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs		Fostamatinib
Diseases
GWAS		Mean platelet volume ( 32888494) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		16 interacting genes: BANP CALM1 CTDP1 H2AC20 H2BC21 H3C6 HERC5 HRAS MOB2 S100B SENP2 TRAF3 TRIM14 TRIM25 YWHAB YWHAZ	57 interacting genes: AMFR APC DDX58 ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZNF24
Entrez ID		11329	7706
HPRD ID		09511	02711
Ensembl ID		ENSG00000112079	ENSG00000121060
Uniprot IDs		A0A024RD18 Q15208	Q14258
PDB IDs		1PSB 6BXI	4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?
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