STK38 and HERC5

Data Source:
BioGRID (pull down)

		STK38	HERC5
Description		serine/threonine kinase 38	HECT and RLD domain containing E3 ubiquitin protein ligase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Cadherin Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ISG15 Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Polyubiquitination Protein Ubiquitination Protein Phosphopantetheinylation ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Mean platelet volume ( 32888494) Subclinical trait of interstitial lung disease (basilar percentage of high attenuation areas on CT scan) ( 28521775) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: BANP CALM1 CTDP1 H2AC20 H2BC21 H3C6 HERC5 HRAS MOB2 S100B SENP2 TRAF3 TRIM14 TRIM25 YWHAB YWHAZ	15 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NME2 PITX2 STK38 UBE2D1 UBE2D2 UBE2L6
Entrez ID		11329	51191
HPRD ID		09511	10502
Ensembl ID		ENSG00000112079	ENSG00000138646
Uniprot IDs		A0A024RD18 Q15208	B4DXV3 Q9UII4
PDB IDs		1PSB 6BXI
Enriched GO Terms of Interacting Partners?
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