TRIM25 and ZNF24

Data Source:
BioGRID (two hybrid)

		TRIM25	ZNF24
Description		tripartite motif containing 25	zinc finger protein 24
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Nucleus Nucleoplasm
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Regulation Of Protein Localization Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor	Regulation Of Transcription By RNA Polymerase II Myelination Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Height ( 18391951) Lean body mass ( 28552196)
Interacting Genes		57 interacting genes: AMFR APC DDX58 ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZNF24	54 interacting genes: APLP1 CCDC130 CEP126 COPS6 CRMP1 DDX6 DZIP3 EEF1A1 EEF1G ERG28 FAM161A FANCA HAP1 HMGB1 KAT5 LMO1 LMO2 LRIF1 MAP1LC3C MID2 MZF1 NEK6 PPP1CC PRPF31 RBM48 SCAND1 SEC62 SETDB1 TCAF1 TP53 TRIM25 TRIM41 UBE2I UNC119 UTP14A ZBTB16 ZGPAT ZKSCAN4 ZKSCAN8 ZNF165 ZNF174 ZNF232 ZNF396 ZNF410 ZNF444 ZNF446 ZNF620 ZNHIT3 ZSCAN12 ZSCAN16 ZSCAN21 ZSCAN22 ZSCAN23 ZSCAN32
Entrez ID		7706	7572
HPRD ID		02711	01921
Ensembl ID		ENSG00000121060	ENSG00000172466
Uniprot IDs		Q14258	P17028
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	1X6E 3LHR
Enriched GO Terms of Interacting Partners?
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