PARK7 and MAPKAPK5

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfer, enzymatic study)

		PARK7	MAPKAPK5
Description		Parkinsonism associated deglycase	MAPK activated protein kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Cytosol Plasma Membrane Adherens Junction PML Body Axon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity MRNA Binding Signaling Receptor Binding Copper Ion Binding Protein Binding Transcription Factor Binding Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Oxygen Sensor Activity Enzyme Binding Kinase Binding Cytokine Binding Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Protein Deglycase Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Cadherin Binding Mercury Ion Binding Androgen Receptor Binding Peroxiredoxin Activity Repressing Transcription Factor Binding Scaffold Protein Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity	P53 Binding Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus DNA Repair Negative Regulation Of Protein Kinase Activity Proteolysis Protein Deglycosylation Autophagy Inflammatory Response Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Methylglyoxal Metabolic Process Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Histone Modification Lactate Biosynthetic Process Insulin Secretion Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of TRAIL Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Histone Ubiquitination Negative Regulation Of Protein Sumoylation Positive Regulation Of NAD(P)H Oxidase Activity Cellular Response To Oxidative Stress Regulation Of Histone Acetylation Cellular Response To Glyoxal Peptidyl-cysteine Deglycation Peptidyl-arginine Deglycation Peptidyl-lysine Deglycation Protein Deglycation, Glyoxal Removal Protein Deglycation, Methylglyoxal Removal Glutathione Deglycation Glucose Homeostasis Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Membrane Hyperpolarization Negative Regulation Of Cell Death Regulation Of Androgen Receptor Signaling Pathway Methylglyoxal Catabolic Process To Lactate Cellular Response To Hydrogen Peroxide Detection Of Oxidative Stress Cellular Oxidant Detoxification Guanine Deglycation Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Cellular Detoxification Of Aldehyde Cellular Detoxification Of Methylglyoxal Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Protein Acetylation Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Metabolic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Positive Regulation Of L-dopa Decarboxylase Activity Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Androgen Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping
Pathways		SUMOylation of transcription cofactors Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs		Copper	Fostamatinib
Diseases		Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576) Celiac disease ( 20190752) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ischemic stroke ( 24262325) Ulcerative colitis ( 28067908 21297633)	Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254)
Interacting Genes		24 interacting genes: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC GPX4 HIPK1 HSPA5 MAPK8IP1 MAPKAPK5 NDUFA4 PIAS2 PINK1 PPP2R1A PPP2R1B SNCA SOD1 SUMO1 UBA2 UBE2I	29 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576
Entrez ID		11315	8550
HPRD ID		03961	09467
Ensembl ID		ENSG00000116288	ENSG00000089022
Uniprot IDs		Q99497 V9HWC2	Q8IW41
PDB IDs		1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8 4BTE 4MNT 4MTC 4N0M 4N12 4OGF 4OQ4 4P2G 4P34 4P35 4P36 4RKW 4RKY 4S0Z 4ZGG 5IP5 5SY6 5SY9 5SYA 6AF5 6AF7 6AF9 6AFA 6AFB 6AFC 6AFD 6AFE 6AFF 6AFG 6AFH 6AFI 6AFJ 6AFL 6E5Z 6M8Z 7C62
Enriched GO Terms of Interacting Partners?
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