CMTM7 and BSCL2

Data Source:
BioGRID (two hybrid)

		CMTM7	BSCL2
Description		CKLF like MARVEL transmembrane domain containing 7	BSCL2 lipid droplet biogenesis associated, seipin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Lipid Droplet Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Cytokine Activity Protein Binding	Protein Binding Phospholipid Binding
	Biological Process	B-1a B Cell Differentiation Chemotaxis Signal Transduction	Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation
Pathways
Drugs
Diseases			Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
GWAS		Copper levels ( 26025379) Hallux valgus ( 32131869) IgM levels ( 28628107) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		47 interacting genes: ADTRP AGER AQP6 ARL13B B3GAT1 BIK BSCL2 CD74 CD79A CLSTN3 CREB3L1 DAGLA DNAJC1 ELOVL4 FAM174A FAM209A FFAR2 FRMD3 GGT7 GORAB HAS3 HIBADH HSD17B13 LDLRAD1 LHFPL5 LMNA MS4A4A MUC1 PAGE1 PIANP PSMD6 RETREG3 SDC3 SHISA3 SLC14A2 SLC30A8 SSMEM1 STX1A TCTA TEX29 THAP4 TMEM106C TMEM174 TMEM31 TMPRSS2 TMX2 TNFRSF17	38 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 FAM20B GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 STRIT1 TEX37 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3
Entrez ID		112616	26580
HPRD ID		06988	05858
Ensembl ID		ENSG00000153551	ENSG00000168000
Uniprot IDs		F8WDZ3 Q96FZ5	A0A024R540 A0A024R549 Q96G97
PDB IDs			6DS5
Enriched GO Terms of Interacting Partners?
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