CMTM7 and AGER

Data Source:
BioGRID (two hybrid)

		CMTM7	AGER
Description		CKLF like MARVEL transmembrane domain containing 7	advanced glycosylation end-product specific receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Integral Component Of Membrane	Fibrillar Center Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Cell Junction Postsynapse
	Molecular Function	Cytokine Activity Protein Binding	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding S100 Protein Binding Protein-containing Complex Binding Advanced Glycation End-product Receptor Activity
	Biological Process	B-1a B Cell Differentiation Chemotaxis Signal Transduction	Response To Hypoxia Microglial Cell Activation Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Protein Phosphorylation Endocytosis Inflammatory Response Cell Surface Receptor Signaling Pathway Learning Or Memory Response To Wounding Glucose Mediated Signaling Pathway Neuron Projection Development Negative Regulation Of Interleukin-10 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of JUN Kinase Activity Transcytosis Innate Immune Response Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Synaptic Plasticity Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of DNA Binding Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotactic Protein-1 Production Protein Localization To Membrane Modulation Of Age-related Behavioral Decline Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Long-term Synaptic Depression Regulation Of P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Blood Circulation Positive Regulation Of Endothelin Production Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Response To Amyloid-beta Cellular Response To Amyloid-beta Positive Regulation Of Monocyte Extravasation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Dendritic Cell Differentiation
Pathways			TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS		Copper levels ( 26025379) Hallux valgus ( 32131869) IgM levels ( 28628107) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Advanced glycation end-product levels ( 26083729) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood protein levels in cardiovascular risk ( 28369058) Chronic obstructive pulmonary disease ( 28166215 30804561) Emphysema imaging phenotypes ( 26030696) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Percentage gas trapping ( 26030696) Prostate cancer ( 23535732) Pulmonary function ( 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Response to Pazopanib in cancer (hepatotoxicity) ( 26546620) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908)
Interacting Genes		47 interacting genes: ADTRP AGER AQP6 ARL13B B3GAT1 BIK BSCL2 CD74 CD79A CLSTN3 CREB3L1 DAGLA DNAJC1 ELOVL4 FAM174A FAM209A FFAR2 FRMD3 GGT7 GORAB HAS3 HIBADH HSD17B13 LDLRAD1 LHFPL5 LMNA MS4A4A MUC1 PAGE1 PIANP PSMD6 RETREG3 SDC3 SHISA3 SLC14A2 SLC30A8 SSMEM1 STX1A TCTA TEX29 THAP4 TMEM106C TMEM174 TMEM31 TMPRSS2 TMX2 TNFRSF17	10 interacting genes: APP C3orf52 CMTM7 CREB3 HMGB1 S100A1 S100A12 S100B S100P TTR
Entrez ID		112616	177
HPRD ID		06988	02568
Ensembl ID		ENSG00000153551	ENSG00000204305
Uniprot IDs		F8WDZ3 Q96FZ5	A0A1U9X785 B4DNX3 Q15109
PDB IDs			1PWI 2BJP 2E5E 2ENS 2L7U 2LE9 2LMB 2M1K 2MJW 2MOV 3CJJ 3O3U 4LP4 4LP5 4OF5 4OFV 4OI7 4OI8 4P2Y 4XYN 4YBH 5D7F
Enriched GO Terms of Interacting Partners?
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