EGLN3 and HIF3A

Data Source:
HPRD (in vitro)

		EGLN3	HIF3A
Description		egl-9 family hypoxia inducible factor 3	hypoxia inducible factor 3 subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Dimerization Activity
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Regulation of gene expression by Hypoxia-inducible Factor Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation
Drugs		Ascorbic acid Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Red blood cell count ( 32888494)	Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)
Interacting Genes		38 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL
Entrez ID		112399	64344
HPRD ID		06972	17104
Ensembl ID		ENSG00000129521	ENSG00000124440
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	B2RBI6 H0YDZ5 M0R104 Q9Y2N7
PDB IDs			4WN5
Enriched GO Terms of Interacting Partners?
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