EGLN3 and OS9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		EGLN3	OS9
Description		egl-9 family hypoxia inducible factor 3	OS9 endoplasmic reticulum lectin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Transmembrane Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs		Ascorbic acid Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Red blood cell count ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		38 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A HSP90B1 LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B
Entrez ID		112399	10956
HPRD ID		06972	17804
Ensembl ID		ENSG00000129521	ENSG00000135506
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q13438
PDB IDs			3AIH
Enriched GO Terms of Interacting Partners?
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