EGLN3 and DUSP7

Data Source:
BioGRID (two hybrid)

		EGLN3	DUSP7
Description		egl-9 family hypoxia inducible factor 3	dual specificity phosphatase 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Population Proliferation Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of MAP Kinase Activity
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs		Ascorbic acid Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ABI2 ADRB2 ATF4 CTBP2 DUSP7 EFHC2 EPAS1 EPOR FAM168B FOXJ2 GSC2 HIF1A HIF3A IK IKBKG IKZF3 LDB2 LNX1 MAPK1 MAPK7 MDM2 NCAPH2 NTAQ1 OS9 PKM PLEKHA2 PRPF19 RBBP8NL SERTAD1 SIAH2 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83 ZC2HC1A ZNF655	7 interacting genes: EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8
Entrez ID		112399	1849
HPRD ID		06972	04125
Ensembl ID		ENSG00000129521	ENSG00000164086
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q16829
PDB IDs			4Y2E
Enriched GO Terms of Interacting Partners?
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