IL24 and FBXW7

Data Source:
BioGRID (two hybrid)

		IL24	FBXW7
Description		interleukin 24	F-box and WD repeat domain containing 7
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Cytokine Activity Protein Binding	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity
	Biological Process	Apoptotic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Migration Wound Healing Serine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development
Pathways		Interleukin-20 family signaling	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		25 interacting genes: AKT1 APC ATM BAG4 CASP8 CCR5 CLU DCD ESR2 FBXW7 HMMR HRAS IL20RA KRAS LSP1 NOTCH2 PALB2 PARP1 PIK3CA PTEN RAD51 RARG RB1CC1 RIPK3 SMAD4	77 interacting genes: AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 EBNA1BP2 EXT1 EZH2 FANCC FBP1 FBP2 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SEC61B SHC1 SHPRH SKP1 SMAD1 SOX9 SREBF1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TP53 TSC22D4 USP9X WDR97 XPA ZNF510
Entrez ID		11009	55294
HPRD ID		04995	05888
Ensembl ID		ENSG00000162892	ENSG00000109670
Uniprot IDs		Q13007	G0Z2K0 Q969H0 S4R3U4
PDB IDs		6DF3 6GG1	2OVP 2OVQ 2OVR 5IBK 5V4B
Enriched GO Terms of Interacting Partners?
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