FBXW7 and LINGO1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FBXW7	LINGO1
Description		F-box and WD repeat domain containing 7	leucine rich repeat and Ig domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity	Epidermal Growth Factor Receptor Binding Protein Binding
	Biological Process	Protein Polyubiquitination Vasculogenesis Vasculature Development Sister Chromatid Cohesion Notch Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Viral Process Protein Ubiquitination Lung Development SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Regulation Of Protein Localization Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Notch Signaling Pathway Rhythmic Process Protein Stabilization Positive Regulation Of Ubiquitin-protein Transferase Activity Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Negative Regulation Of Axonogenesis
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494)	Adult body size ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Essential tremor ( 19182806) Feeling miserable ( 29500382) General factor of neuroticism ( 30867560) Hemoglobin A1c levels ( 29403010) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neuroticism ( 27089181) Risky sexual behaviors (alcohol dependence interaction) ( 28990359) Systemic lupus erythematosus ( 33536424)
Interacting Genes		77 interacting genes: AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 EBNA1BP2 EXT1 EZH2 FANCC FBP1 FBP2 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NOTCH1 NOTCH4 NPM1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 PTPN11 RACK1 RFLNA SCGB3A1 SEC61B SHC1 SHPRH SKP1 SMAD1 SOX9 SREBF1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TP53 TSC22D4 USP9X WDR97 XPA ZNF510	17 interacting genes: EFEMP2 FBLN1 FBXW7 FRS3 GOLGA2 HSD3B7 KRTAP10-1 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP9-2 MACO1 NGFR NTM RTN4R SPAG5 TRIM27
Entrez ID		55294	84894
HPRD ID		05888	14322
Ensembl ID		ENSG00000109670	ENSG00000169783
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	Q96FE5
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B	2ID5 4OQT
Enriched GO Terms of Interacting Partners?
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