SMC2 and LIG4

  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vitro, in vivo, two hybrid)

SMC2

LIG4

Description structural maintenance of chromosomes 2 DNA ligase 4
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653)
  • Apolipoprotein A1 levels ( 32203549)
  • Basal cell carcinoma ( 31174203)
  • HDL cholesterol levels ( 32203549)
  • Keratinocyte cancer (MTAG) ( 31174203)
  • Oily fish consumption ( 32066663)
  • Orofacial clefts (maternal alcohol consumption interaction) ( 21618603)
  • Pancreatic cancer ( 29422604)
  • Pancreatic ductal adenocarcinoma ( 30541042)
  • Pork consumption ( 32066663)
  • Sensorimotor dexterity ( 31596458)
  • Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
  • Irritable bowel syndrome ( 29626450)
Interacting Genes 11 interacting genes: ABCC5 CDC42 DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 SUMO2 TRAF3IP1 103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT
Entrez ID 10592 3981
HPRD ID 09277 03500
Ensembl ID ENSG00000136824 ENSG00000174405
Uniprot IDs A0A024R158 A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1 A0A024RE06 A0A0C4DGV9 A8K8Q4 P49917
PDB IDs 4U4P 1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG
Enriched GO Terms of Interacting Partners?
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