CLEC10A and TMEM218

Data Source:
BioGRID (two hybrid)

		CLEC10A	TMEM218
Description		C-type lectin domain containing 10A	transmembrane protein 218
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Cilium Integral Component Of Membrane
	Molecular Function	Protein Binding Carbohydrate Binding	Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Endocytosis Innate Immune Response
Pathways		Dectin-2 family
Drugs
Diseases
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Neurological blood protein biomarker levels ( 31320639)	Breast cancer (survival) ( 25890600) Familial lung adenocarcinoma ( 29924316)
Interacting Genes		24 interacting genes: ACSF2 ADIPOQ APOD BET1 C3orf52 CLN6 FMO3 FXYD6 GIMAP1 MALL NAPB PEX16 PRAF2 SEC22A SLC38A7 SMCO4 TMEM218 TNF TRARG1 TSPO UNC50 VSTM1 ZDHHC15 ZFPL1	72 interacting genes: APH1A AQP2 AQP6 ARL13B ASZ1 ATP6V0E1 BSCL2 CD300A CD53 CD79A CLDN2 CLEC10A CLEC17A CPLX4 CREB3L1 CTLA4 DAGLA EBP ELOVL2 ELOVL4 EMP1 ERGIC3 FAM209A FCER1G FRMD3 GDAP1 GJB1 GJB4 GJB6 GPR152 GPR61 GPX8 IFNGR2 KCNJ6 KCNK5 KIR2DL3 LDLRAD1 LHFPL5 LMNA LSMEM2 MFF MS4A3 MTIF3 NPFFR2 PCNA PDCD1LG2 PIK3IP1 PLEKHO1 PSCA RETREG3 SAR1A SDC3 SLC10A4 SLC10A6 SLC18A1 SMIM3 SSMEM1 TM4SF18 TMED8 TMEM106C TMEM182 TMEM207 TMEM234 TMEM31 TMEM45B TMEM52B TMEM88 TMPRSS2 TRHR TSPAN12 TSPAN18 VSIR
Entrez ID		10462	219854
HPRD ID		12076	19054
Ensembl ID		ENSG00000132514	ENSG00000150433
Uniprot IDs		J3KR22 Q8IUN9	A2RU14
PDB IDs		6PUV 6PY1
Enriched GO Terms of Interacting Partners?
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