RAPGEF3 and RRAS2

Data Source:
HPRD (in vitro)

		RAPGEF3	RRAS2
Description		Rap guanine nucleotide exchange factor 3	RAS related 2
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GO Annotations	Cellular Component	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Angiogenesis Signal Transduction CAMP-mediated Signaling Rap Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP Positive Regulation Of Protein Acetylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Histone H3-K9 Acetylation	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1	32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		10411	22800
HPRD ID		06928	02518
Ensembl ID		ENSG00000079337	ENSG00000133818
Uniprot IDs		O95398 Q99777	P62070
PDB IDs		6H7E	2ERY
Enriched GO Terms of Interacting Partners?
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