RAPGEF3 and OARD1

Data Source:
BioGRID (two hybrid)

		RAPGEF3	OARD1
Description		Rap guanine nucleotide exchange factor 3	O-acyl-ADP-ribose deacylase 1
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GO Annotations	Cellular Component	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome	Nucleoplasm Nucleolus Site Of DNA Damage
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding	Purine Nucleoside Binding Protein Binding O-acetyl-ADP-ribose Deacetylase Activity ADP-ribosylglutamate Hydrolase Activity
	Biological Process	Angiogenesis Signal Transduction CAMP-mediated Signaling Rap Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP Positive Regulation Of Protein Acetylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Histone H3-K9 Acetylation	Cellular Response To DNA Damage Stimulus Purine Nucleoside Metabolic Process Protein De-ADP-ribosylation Peptidyl-glutamate ADP-deribosylation
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Adult body size ( 32376654) Alzheimer's disease (late onset) ( 30820047) Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1	4 interacting genes: APP PICK1 RAPGEF3 TNKS
Entrez ID		10411	221443
HPRD ID		06928	12849
Ensembl ID		ENSG00000079337	ENSG00000124596
Uniprot IDs		O95398 Q99777	A0A024RCY9 C9J5P1 C9JA90 C9JXC3 Q05CR9 Q9Y530
PDB IDs		6H7E	2EEE 2L8R 2LGR 4J5Q 4J5R 4J5S
Enriched GO Terms of Interacting Partners?
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