RAPGEF3

Description		Rap guanine nucleotide exchange factor 3
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GO Annotations	Cellular Component	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding
	Biological Process	Angiogenesis Signal Transduction CAMP-mediated Signaling Rap Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP Positive Regulation Of Protein Acetylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Histone H3-K9 Acetylation
Pathways		Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Novel Interacting Genes		1 novel interacting genes: SP1
Interacting Genes		14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1
Entrez ID		10411
HPRD ID		06928
Ensembl ID		ENSG00000079337
Uniprot IDs		O95398 Q99777
PDB IDs		6H7E
Enriched GO Terms of Interacting Partners?
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